Alexandria Justice

Main cast

 * Tom Kenny as County Attorney, later Justice Minister Andrew Mendoza Gillan, Head of LeMode, a Law Office in Cordelia, the Capital of North Alexandria, he is a Primary Protagonist in the Show.
 * Hyubs Azarcon as Eric "Resnick" Fajardo †, Andrew's Shy Assistant
 * Melanie Marquez as Speaker of the Assembly Louise Davis †, who's is Andrew's Love Interest.
 * Eric Quizon as Terry Davis †, Louise's Ex-Husband
 * Julia Barretto as District Attorney Anne-Sophie Castillo, The 18 year-old lawyer works for LeMode and Leighton's mistress
 * Christopher de Leon as Angelito Castillo, Anne-Sophie's Father
 * Lorna Tolentino as Natalie Castillo, Anne Sophie's Mother
 * Vic Robinson II as Tipton, Anne-Sophie Assistant
 * Enchong Dee as District Attorney, later County Attorney James Lewis, The 8-year veteran of LeMode Law Office, Anne-Sophie's Love Interest.
 * Perla Bautista as Sarah Custodio, James' Stepmother who Love's him.
 * Ronnie Alonte as Attorney Alan Roque, The Lawyer of their Rival Angency, A-FIX Law Office, a Conservative Legal agency
 * Susan Africa as DA Tess Patrick-Roque, Alan's Mother who also a Lawyer.
 * Juan Karlos Labajo as District Attorney Chris Bailey, The 15 year-old lawyer works for LeMode
 * Robert Arevalo as Leo Bailey†, Chris Grandfather who Likes Motorsports (i.e. NASCAR, F1, etc.).
 * Hannah Lopez Vito as Attorney Abigail Mendoza, The 10 year-old works for LeMode, by Mistaking her Name in the Test for Lawyers.
 * Jane Ointeza as Louise Mendoza, sister to Abigail
 * Teejay Marquez as Mike Mendoza, Brother to Abigail
 * Tirso Cruz III as Henry Spencer†, Former Justice Minister of Alexandria and Justice Minister of Alodia, he is the Primary Antagonist of the Show.
 * Jameson Blake as Leighton Spencer, Lacey's Husband, Henry's Son and Blake's Father and Anne-Spohie'
 * Ria Atayde as Lacey D'Olivo-Spencer, Henry's Daughter-in-Law, Leighton's Divorced Wife and Blake's Mother
 * Izzy Canillo as Blake Spencer, Henry's Grandson and Abigail's Love Interest
 * RK Bagatsing as Mayor Peter Spencer, Henry's Son, Leighton's Brother and Mayor of Cordelia
 * Pilar Pilapil as Deputy County Attorney Dahlia Ossi†, Head of A-FIX, a Rival Law Office of LeMode, she is the Secondary Antagonist of the Show.
 * Andrea Brillantes as DA Bethanie Grant-Ward†, head of Nine&Ten, another Law Office in Alexandria
 * TJ Trinidad as Attorney Patrick†, who is Tomas Tuazon's Lawyer (in Ang Probisyano) and Andrew's Friend/Partner loyal in his LeMode Agency.
 * Maricar Reyes as Therese Jordan, Mother to Abigail
 * Matet de Leon as Former Premier and MP Amanda Pearson
 * Christopher Walken as Adrian Thomas Gillan, Andrew's Father

Judges

 * Irma Adlawan as Judge, later Supreme Court Justice Wilma Ocampo
 * Arlene Muhlach as Judge Phoebe Asuncion
 * Bernard Palanca as Judge Christopher dela Cruz and Amanada's Love Interest
 * Justin Cuyugan as Judge Eliseo Tan
 * Alvin Anson as County Court Head Justice David Boyle

A-FIX

 * Khalil Ramos as District Attorney Constantino Padilla†, The 5-year Veteran of A-FIX
 * Katrina Legaspi as Barrister Ainslinn Lim, The 3-year Veteran of A-FIX
 * Prince Stefan as Barrister Artemio Suarez, The 8-year Veteran of A-FIX
 * Pamu Pamorada as Barrister Michelle Reyes, The 2-year Veteran of A-FIX
 * Marco Pingol as DA Philip "Pepe" Ward a Member of A-FIX
 * Lucie Jones as DA Armie Lena a New Member of A-FIX

Nine&Ten

 * Minnie Aguilar as Nine&Ten Lawyer
 * Lui Manansala as Nine&Ten Lawyer
 * Patricia Ysmael as Nine&Ten Lawyer
 * Miguel Gabriel Diokno as Nine&Ten Lawyer

Politicians

 * Anna Marin as Setiptonist Leader Madeleine Winer
 * Jenine Desiderio as Socialist Leader, later Premier Nicole Kendall

Others

 * Deniesse Joaquin as Marja Helinen
 * Sam Thurman as Bill Rogers
 * Carla Martinez as Samantha Robinson
 * Mark Oblea as Bandleader of the Alexandria Symphony.
 * Toby Alejar as Former County Attorney Frederick Oswald U. Ryle
 * Victor Silayan as District Attorney Albert Santos, a Retired lawyer.
 * Margo Midwinter as Mayor Aguirre
 * Kyra Custodio as Assemblywoman Rosario
 * Josh Ivan Morales as Honesto
 * Twinkle Dy as Assemblywoman Lorna
 * Roy Requejo as Assemblyman Davis
 * Chris Tan as Vice-Mayor Cameron
 * Marianne Guidotti as Talley
 * Richard Manabat as PO1 Santos
 * Dwight Gaston as LeMode Janitor
 * Jade Ecleo as Assemblywoman Glenda
 * Chiqui del Carmen as Eurovision Votes Spokesperson
 * Lance Lucido as Assemblyman Michael K.Fox
 * Aaliyah Belmoro as Assemblywoman Ochoa
 * Miguel Diokno as Assemblyman Noah
 * Joe Vargas as Assemblyman Legaspi
 * Claire Ruiz as Assemblywoman Davis

Special Guest

 * Erik Santos as Himself
 * Måns Zelmerlöw as Himself
 * Lito Pimentel as Himself
 * Vandolph Quizon as Lito's Manager
 * Jack Batallones as Police officer
 * Wendell Ramos as Vice Mayor Cipriano "Ryan" Santos, Jr.
 * Erika Padilla as PBA Courtside Reporter
 * Bobby Andrews as Chad Knaus
 * Albert Martinez as Mang Romy
 * Xian Lim as DA Roland Fraser
 * Daniel Matsunaga as DA Nathan Davis
 * Angelica Pangaliban as Herself
 * Rey Gumatas as Ryan
 * Petra Mede as Herself
 * Isabelle Daza as Luisa
 * Bangs Garcia as Denise
 * Stefan Raab as Heiko
 * Noni Buencamino as Himself
 * Jim Carrey as John Board
 * David Murray as Himself
 * Jake Cuenca as Himself
 * Michael de Mesa as Lito Marquez
 * Luis Manzano as Boni
 * Sean Bean as Prime Minister
 * Famke Janssen as Opposition Leader

Crossover with Homecoming

 * on 27 and 28 February.